Brentford produced a stunning first-half performance as they scored four goals in the first 35 minutes to condemn Manchester United to a humiliating defeat at Gtech Community Stadium.
Despite fielding their best including Cristiano Ronaldo, United team lacked everything needed to contest for even top six, not to talk of top four or winning the title.
Josh Dasilva put the hosts ahead when his strike from distance somehow eluded United goalkeeper David de Gea.
Mathias Jensen doubled the lead after dispossessing former Brentford player Christian Eriksen, with Ben Mee and Bryan Mbeumo goals putting Thomas Frank’s side four up during an incredible first half in which they dismantled United in stunning fashion.
The defeat is United’s seventh in a row on the road – their worst run since 1936 – while it is the seventh time they have conceded at least four goals in a league game since the start of last season.
While Brentford can bask in a historic win, United boss Erik ten Hag faces the unenviable task of lifting his players in time for the visit of Liverpool to Old Trafford on Monday, 22 August.